46-vehicle pile-up in multiple crashes on eastbound Interstate 94 near Michigan City, Indiana Friday Jan 24,2014

Forty-six vehicles, including 17 tractor-trailers and two other trucks, crashed in icy conditions, shutting down eastbound Interstate 94 near Michigan City, Indiana, likely until early on Friday morning, Indiana State Police spokeswoman Ann Wojas said.

Snow fall had reduced visiblity to the point of "whiteout conditions" along the stretch of highway, Wojas said.

Firefighters working hours after the crash were able to pull another injured person from a vehicle and were focusing on clearing the wreckage and searching for other casualties, Wojas said.

At least three people were killed and more than 20 injured.One critically injured patient among 13 transported to Franciscan St. Anthony Health facility in Michigan City had died and the other 12 suffered moderate and minor injuries